Rat Burana was once an agricultural area. Now it has been developed into residential and industrial zones. Rat Burana is divided into the sub-districts of Rat Burana and Bang Pakok, covering 21 villages in all.

Rat Burana, which lies on the southern part of Bangkok, played a significant role when Thon Buri was established as the new capital by King Taksin. The district was formed during the integration of Thon Buri and Bangkok in 1972.